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National Down Syndrome Society (NDSS)

Their website provides a lot of resources and information about Down syndrome and a free helpline to answer questions about Down syndrome.
Headquarters: 8 East Forty-first Street, New York, New York 10017
National Advocacy & Public Policy Center: 1100 H Street Northwest, Washington, DC 20005
National Helpline: (800) 221-4602
ndss.org